Alternative Names & Classifications:
Glucagonoma (CLINICAL)
Description
A glucagonoma is a typically malignant tumor arising from the alpha cells of the pancreatic islets of Langerhans. The tumor constantly secretes massive amounts of glucagon, the hormone responsible for raising blood sugar by triggering the liver to break down glycogen and synthesize new glucose. The clinical presentation is defined by the catabolic effects of this hormone overload, deeply affecting skin, metabolism, and coagulation.