Alternative Names & Classifications:
Hutchinson-Gilford Progeria Syndrome (CLINICAL), Progeria (CLINICAL)
Description
Progeria is caused by a sporadic, dominant mutation in the LMNA gene, leading to the production of an abnormal protein called progerin. Progerin destabilizes the cell nucleus, causing premature cellular aging and death throughout the body. Children with this condition typically succumb to severe cardiovascular disease by their teenage years.