Alternative Names & Classifications:
McCune-Albright Syndrome (CLINICAL)
Description
McCune-Albright Syndrome is caused by a random, non-inherited somatic mutation in the GNAS gene occurring early in embryonic development. This mutation traps G-proteins in an 'always on' state, causing certain tissues to function autonomously without normal hormonal regulation. It presents with a classic triad: patchy bone lesions, large birthmarks, and early puberty, though it can cause hyperfunction in almost any endocrine gland.