Alternative Names & Classifications:
MEN1 Syndrome (CLINICAL), Multiple Endocrine Neoplasia Type 1 (CLINICAL)
Description
MEN1 is a rare, autosomal dominant hereditary syndrome caused by a germline mutation in the MEN1 tumor suppressor gene. The lack of the functional 'menin' protein predisposes the patient to develop multiple, highly active tumors across the endocrine system over their lifetime. These tumors wildly overproduce various hormones, creating a complex, multi-system clinical picture that requires lifelong screening and management.