Alternative Names & Classifications:
MEN2 Syndrome (CLINICAL), Multiple Endocrine Neoplasia Type 2 (CLINICAL)
Description
MEN2 is an autosomal dominant genetic cancer syndrome caused by a germline mutation in the RET proto-oncogene. It virtually guarantees the development of medullary thyroid carcinoma, an aggressive cancer of the thyroid's C-cells. It also heavily predisposes the patient to developing pheochromocytomas (adrenal tumors) and hyperparathyroidism, requiring prophylactic surgery and lifelong screening for affected families.