Calabar Swelling
Type: Symptom
Definition
Transient, localized, and non-pitting inflammatory edemas that migrate across the body.
Clinical Details
These localized angioedemas are provoked by a type I hypersensitivity reaction to the excretory and secretory antigens of the rapidly migrating adult worms. They frequently appear on the limbs or near joints, causing local tightness and restricted movement, but typically resolve completely within a few days. The unpredictable reappearance of these swellings is a hallmark of the chronic disease.