Confusion
Type: Symptom
Definition
A profound state of cognitive disorientation, altered mentation, and behavioral changes.
Clinical Details
The continuous, progressive demyelination and widespread inflammatory meningoencephalitis directly destroy cortical and subcortical brain tissue. This manifests initially as subtle personality changes and apathy, rapidly progressing to severe confusion, hallucinations, and frank psychosis. The profound cognitive decline mirrors the physical destruction of the brain parenchyma.